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. 2023 Jan 20;9(1):e200055. doi: 10.1212/NXG.0000000000200055

Figure 3. Effects of APOE Genotype on Cognitive Domain–Specific Trajectories.

Figure 3

Model 3–based trajectories for memory- (A), attention- (B), executive- (C), and language-specific (D) composite z scores with the intercept at the time of death calculated for an 86-year-old woman with 15 years of education and autopsy findings of CERAD NP score moderate and Braak NFT stage III/IV. Graphs depict the 3 APOE groups in latent class 1 (slow decliners) and latent class 2 (fast decliners) as well as the differences APOEε4 vs APOEε3 and APOEε2 vs APOEε3. Shaded areas correspond to the 95% CIs. CERAD = Consortium to Establish a Registry for Alzheimer Disease; NFT = neurofibrillary tangle; NP = neuritic plaque.