Table 1. MR results of body fat indexes on the risk of BCa.

Exposure	Method	No. of SNPs	p	OR (95% CI)	p −het	p - intercept	p −global	p −steiger	F statistic
Whole body fat mass	MR Egger	261	0.966	1.020 (0.416–2.502)	0.377	0.358
	Weighted median	261	0.004	1.931 (1.237–3.014)
	Inverse variance weighted	261	0.006	1.518 (1.128–2.042)	0.379			0.000	94.983
	Simple mode	261	0.133	2.726 (0.740–10.047)
	Weighted mode	261	0.043	2.495 (1.032–6.032)
	MR-PRESSO (raw)	261	0.004	1.534 (1.243–1.824)			0.505
Leg fat mass (right)	MR Egger	267	0.304	1.790 (0.592–5.416)	0.452	0.991
	Weighted median	267	0.004	2.301 (1.305–4.059)
	Inverse variance weighted	267	0.002	1.779 (1.246–2.540)	0.469			0.000	93.140
	Simple mode	267	0.457	1.813 (0.379–8.674)
	Weighted mode	267	0.134	2.434 (0.764–7.751)
	MR-PRESSO (raw)	267	0.001	1.799 (1.447–2.150)			0.573
Leg fat mass (left)	MR Egger	266	0.197	2.126 (0.678–6.672)	0.152	0.725
	Weighted median	266	0.005	2.434 (1.307–4.532)
	Inverse variance weighted	266	0.004	1.751 (1.202–2.551)	0.161			0.000	94.237
	Simple mode	266	0.359	2.120 (0.427–10.512)
	Weighted mode	266	0.111	2.491 (0.814–7.621)
	MR-PRESSO (raw)	266	0.002	1.771 (1.404–2.138)			0.264
Arm fat mass (right)	MR Egger	255	0.941	1.033 (0.436–2.446)	0.600	0.245
	Weighted median	255	0.003	2.089 (1.283–3.399)
	Inverse variance weighted	255	0.001	1.672 (1.247–2.243)	0.594			0.000	95.852
	Simple mode	255	0.106	2.868 (0.803–10.241)
	Weighted mode	255	0.048	2.635 (1.014–6.843)
	MR-PRESSO (raw)	255	0.000	1.680 (1.393–1.967)			0.688
Arm fat mass (left)	MR Egger	253	0.736	1.166 (0.477–2.851)	0.180	0.464
	Weighted median	253	0.001	2.230 (1.404–3.541)
	Inverse variance weighted	253	0.003	1.597 (1.175–2.169)	0.186			0.000	96.172
	Simple mode	253	0.086	2.965 (0.863–10.190)
	Weighted mode	253	0.024	2.709 (1.145–6.408)
	MR-PRESSO (raw)	253	0.001	1.642 (1.340–1.945)			0.222
Trunk fat mass	MR Egger	270	0.975	0.986 (0.395–2.460)	0.072	0.460
	Weighted median	270	0.014	1.736 (1.116–2.700)
	Inverse variance weighted	270	0.040	1.366 (1.014–1.841)	0.074			0.000	93.476
	Simple mode	270	0.153	2.506 (0.713–8.816)
	Weighted mode	270	0.081	2.405 (0.901–6.418)
	MR-PRESSO (raw)	270	0.033	1.375 (1.082–1.667)			0.116

Notes.

BCa

bladder cancer

IVW

inverse variance weighted

OR

odds ratio

CI

confidence intervals

p-het

p value for heterogeneity using Cochran Q test

p-intercept

p value for MR-Egger intercept

MR-PRESSO

Mendelian randomization-pleiotropy residual sum outlier

p-global

p value for MR-PRESSO global test

p-steiger

p value for MR-Steiger test

SNP

single-nucleotide polymorphism