Table 3.
Odds Ratios for Macrovascular and Microvascular Complications According to UHR Quartiles by Various Subgroups
| Cases/Participants | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-Trend | P-Interaction | |
|---|---|---|---|---|---|---|---|
| CVD | |||||||
| Age, yearsa | |||||||
| <65 | 1655 /4525 | 1.00 (ref) | 1.24 (0.83,1.83) | 1.26 (0.84,1.89) | 0.94 (0.61,1.43) | 0.488 | 0.432 |
| ≥65 | 2870/4525 | 1.00 (ref) | 1.14 (0.88,1.46) | 1.16 (0.89,1.50) | 1.41 (1.08,1.85) | 0.015 | |
| BMI, kg/m2b | |||||||
| < 24 | 2412/4525 | 1.00 (ref) | 1.16 (0.88,1.52) | 1.22(0.92,1.63) | 1.03 (0.72,1.46) | 0.082 | 0.638 |
| ≥ 24 | 2113/4525 | 1.00 (ref) | 1.12 (0.79,1.59) | 1.08 (0.76,1.53) | 1.43 (1.06,1.94) | 0.022 | |
| Sex c | |||||||
| Male | 2096/4525 | 1.00 (ref) | 1.04 (0.70,1.53) | 0.89 (0.61,1.32) | 0.89 (0.61,1.30) | 0.543 | 0.714 |
| Female | 2429/4525 | 1.00 (ref) | 1.21 (0.93,1.57) | 1.37 (1.05,1.79) | 1.57 (1.17,2.11) | 0.003 | |
| HbA1cd | |||||||
| <7.0% | 1837/4525 | 1.00 (ref) | 1.26 (0.89,1.79) | 1.29 (0.90,1.85) | 1.40 (0.96,2.05) | 0.162 | 0.458 |
| ≥7.0% | 2688/4525 | 1.00 (ref) | 1.14 (0.87,1.49) | 1.18 (0.89,1.56) | 1.24 (0.92,1.61) | 0.175 | |
| CKD | |||||||
| Age, yearsa | |||||||
| <65 | 1581/4360 | 1.00 (ref) | 1.45 (0.94,2.24) | 1.69 (1.09,2.61) | 2.54 (1.62,3.96) | 0.019 | 0.262 |
| ≥65 | 2779/4360 | 1.00 (ref) | 1.23 (0.92,1.64) | 1.83 (1.37,2.46) | 2.21 (1.64,2.99) | <0.001 | |
| BMI, kg/m2b | |||||||
| < 24 | 2421/4360 | 1.00 (ref) | 1.49 (1.09,2.06) | 2.15 (1.55,2.98) | 3.27 (2.33,4.58) | <0.001 | 0.347 |
| ≥ 24 | 1939/4360 | 1.00 (ref) | 1.06 (0.72,1.54) | 1.42 (0.98,2.05) | 1.62 (1.12,2.34) | 0.011 | |
| Sex c | |||||||
| Male | 2020/4360 | 1.00 (ref) | 0.79 (0.51,1.21) | 1.29 (0.86,1.97) | 1.50 (1.00,2.26) | 0.049 | 0.432 |
| Female | 2340/4360 | 1.00 (ref) | 1.57 (1.17,2.11) | 2.01 (1.49,2.72) | 3.09 (2.24,4.26) | <0.001 | |
| HbA1cd | |||||||
| <7.0% | 1775/4360 | 1.00 (ref) | 1.83 (1.20,2.79) | 2.03 (1.32,3.13) | 2.50 (1.59,3.92) | <0.001 | 0.926 |
| ≥7.0% | 2585/4360 | 1.00 (ref) | 1.06 (0.79,1.42) | 1.69 (1.26,2.27) | 2.26 (1.68,3.04) | <0.001 |
Notes: Data are expressed as regression coefficients or odds ratios (95% CI). aFor age subgroup: adjusted for sex, BMI, LDL-C, TC, FBG, HbA1c, eGFR (only in CVD group), smoke status and drink status, systolic blood pressure, diastolic blood pressure, anti-diabetes agents, hypertension, anti-hypertension drug; bFor BMI subgroup: adjusted for age, sex, LDL-C, TC, FBG, HbA1c, eGFR (only in CVD group), smoke status and drink status, systolic blood pressure, diastolic blood pressure, anti-diabetes agents, hypertension, anti-hypertension drug; cFor sex subgroup: adjusted for age, BMI, LDL-C, TC, FBG, HbA1c, eGFR (only in CVD group), smoke status and drink status, systolic blood pressure, Diastolic blood pressure, anti-diabetes agents, hypertension, anti-hypertension drug; dFor HbA1c subgroup: adjusted for age, sex, BMI, LDL-C, TC, FBG, eGFR (only in CVD group), smoke status and drink status, systolic blood pressure, diastolic blood pressure, anti-diabetes agents, hypertension, anti-hypertension drug.