Table 1.
Baseline characteristics of participants
| Control (n = 11) | Hemoadsorption (n = 10) | p value | |
|---|---|---|---|
| Patients’ characteristics | |||
| Age, years | 68 (48, 72) | 72 (63, 77) | 0.16 |
| Charlson score | 5 (1, 5) | 5 (3, 6) | 0.33 |
| Chronic kidney disease (GFR < 30 ml/min) | 1 (9%) | 1 (10%) | 1.00 |
| Chronic heart failure | 1 (9%) | 4 (40%) | 0.15 |
| Diabetes | 3 (27%) | 3 (30%) | 1.00 |
| Hypertension | 9 (82%) | 4 (40%) | 0.08 |
| COPD | 2 (18%) | 1 (10%) | 1.00 |
| Active smoker | 9 (82%) | 5 (50%) | 0.18 |
| Aspirin | 8 (73%) | 2 (20%) | 0.03 |
| Blockers of the renin–angiotensin system | 5 (45%) | 3 (30%) | |
| Cardiac arrest characteristics | |||
| No-flow duration, minutes | 4 (0, 9) | 4 (1, 10) | 0.81 |
| Low-flow duration, minutes | 20 (15, 40) | 30 (22, 45) | 0.31 |
| Time-to-ROSC | 22 (18, 40) | 36 (24, 50) | 0.24 |
| Presenting rhythm | 0.08 | ||
| Non-shockable | 7 (64%) | 2 (20%) | |
| Shockable | 4 (36%) | 8 (80%) | |
| Cause of cardiac arrest | 1.00 | ||
| Ischemic | 5 (45%) | 6 (60%) | |
| Hypoxic | 2 (18%) | 1 (10%) | |
| Other | 4 (37%) | 3 (30%) | |
| Location of cardiac arrest | 0.31 | ||
| In-hospital | 4 (36%) | 1 (10%) | |
| Out-of-hospital | 7 (64%) | 9 (90%) | |
| Laboratory at ICU admission | |||
| Serum creatinine, µmol/L | 117 (92, 204) | 133 (123, 210) | 0.22 |
| Lactate, mmol/L | 7 (5, 12) | 4 (3, 5) | 0.02 |
| Hemoglobin, g/L | 122 (109, 137) | 130 (120, 149) | 0.44 |
| C-reactive protein, mg/L | 5 (2, 18) | 3 (2, 70) | 0.96 |
| Thrombocytes, G/l | 192 (111, 225) | 203 (172, 261) | 0.42 |
| aPTT, sec | 34 (30, 39) | 41 (34, 150) | 0.16 |
| Plasma interleukin-6, pg/mL (at randomization) | 79 (55, 11,296) | 319 (80, 19,653) | 0.40 |
| Scores and vasopressors at randomization | |||
| SOFA score | 12 (9, 13) | 11 (8, 13) | 0.52 |
| Noradrenalin, µg/min | 10 (4, 20) | 16 (6, 32) | 0.60 |
| Targeted temperature management | |||
| Delay ICU admission to TTM, hours | 3 (0.5, 4) | 4 (2, 5) | 0.45 |
| Delay TTM to randomization, hours | 10 (− 0.5, 12) | 8 (0.25, 17) | 0.48 |
| Average temperature during TTM, °C | 35 (35, 36) | 35 (35, 36) | 0.46 |
| Duration of TTM, hours | 23 (17, 24) | 24 (22, 24) | 0.43 |
Data are presented as median (interquartile range—IQR) for continuous measures, and n (%) for categorical measures. Continuous measures are compared with a Wilcoxon rank-sum test and categorical measures are compared with a Fisher's exact test
aPTT activated partial thromboplastin clotting time, COPD chronic obstructive pulmonary disease, GFR glomerular filtration rate, ICU intensive care unit, ROSC return of spontaneous circulation, TTM targeted temperature management