Table 2.

Efficacy outcome: reduction in cytokines plasma levels within 48 h post-randomization

	Control (n = 10*)	Hemoadsorption (n = 8*)	Total (n = 18)	p value
IL-6
Absolute reduction, pg/mL	4.18 (− 13, 639)	143 (42, 19,555)	43 (− 7, 792)	0.38
Relative reduction, %	5 (− 47, 7)	75 (60, 94)	60 (− 13, 86)	0.06
IL-8
Absolute reduction, pg/mL	59 (10, 187)	181 (21, 345)	128 (16, 266)	0.37
Relative reduction, %	72 (13, 90)	90 (68, 98)	83 (33, 93)	0.06
IL-10
Absolute reduction, pg/mL	15 (4, 140)	82 (0.15, 617)	20 (2, 366)	0.59
Relative reduction, %	62 (41, 76)	91 (35, 99)	75 (41, 92)	0.20
TNF-α
Absolute reduction, pg/mL	0.15 (− 0.46, 1.71)	1.35 (− 0.25, 1.56)	0.84 (− 0.46, 1.56)	0.72
Relative reduction, %	60 (5, 100)	100 (96, 100)	98 (25, 100)	0.29
IL-5
Absolute reduction, pg/mL	0.12 (− 0.41, 0.83)	1.35 (0.09, 3.00)	0.78 (− 0.41, 1.51)	0.25
Relative reduction, %	20 (2, 100)	100 (89, 100)	94 (4, 100)	0.10
IL-2
Absolute reduction, pg/mL	0.00 (0.00, 3.58)	3.47 (− 2.63, 6.59)	0.00 (0.00, 5.26)	0.39
Relative reduction, %	77 (35, 90)	82 (63, 100)	77 (63, 100)	0.67
IL-4
Absolute reduction, pg/mL	0.00 (− 1.60, 1.39)	12.35 (1.20, 37.97)	0.69 (− 1.39, 13.57)	0.07
Relative reduction, %	38 (− 14, 93)	84 (72, 97)	75 (16, 97)	0.47
GM-CSF
Absolute reduction, pg/mL	0.04 (− 0.35, 0.35)	0.65 (0.02, 3.86)	0.13 (− 0.21, 1.20)	0.16
Relative reduction, %	2 (− 14, 16)	27 (2, 49)	8 (− 14, 31)	0.16

Data are presented as median (interquartile range—IQR), and compared between groups with Fisher exact test

Absolute reduction is calculated as: (value at randomization - value at 48 h)

Relative reduction is calculated as the ratio of the absolute reduction over the value at randomization. This ratio could not be calculated when value at randomization was under detection threshold

*One patient in each group died within 48 h, reduction at 48 h could be evaluated in 10 patients in the control group and 8 patients in the hemoadsorption group