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. 2022 Feb 1;77(2):395–410. doi: 10.1002/hep.32317

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of American Association for the Study of Liver Diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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Dysregulation of the TRAF3–NIK axis is associated with advanced stage and poor prognosis of human ICC. (A) Representative images of ICCs with low TRAF3 expression and high NIK expression (upper panels) and ICCs with high TRAF3 expression and low NIK expression (lower panels). (B) Correlation between TRAF3 and NIK staining intensity in tumor tissue of patients with ICC. Scale bars, 50 μm. DFS (C) and OS (D) based on TRAF3 staining intensity in patients with ICC. DFS (E) and OS (F) based on NIK staining intensity in patients with ICC. HE, hematoxylin and eosin; NT, nontumor; T, tumor