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. 2022 Dec 22;7(24):e155147. doi: 10.1172/jci.insight.155147

Figure 2. Evaluation of quadriceps and diaphragm fiber type atrophy in skeletal muscle from C26 tumor–bearing mice.

Figure 2

Analysis of fiber histology on MHC isoforms of PBS and C26 mice was performed. CSA of MHC stains was evaluated in the quadriceps (A, n = 8; B, representative image; original magnification, ×20) and diaphragm at 2 weeks of tumor bearing (C, n = 6; D, representative image; original magnification, ×20). The same was completed for the quadriceps (E, n = 9; F, representative image; original magnification, ×20) and diaphragm at 4 weeks of tumor bearing (G, n = 9; H, representative image; original magnification, ×20). Results represent mean ± SD; 2-tailed t tests were used to determine the difference between PBS(2wk) versus C26(2wk) and PBS (4wk) versus C26(4wk). *P < 0.05 PBS (4wk) versus C26(4wk).