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. 2022 Dec 22;7(24):e155147. doi: 10.1172/jci.insight.155147

Figure 3. The effects of C26 colon cancer on the activation of atrophy markers in quadriceps and diaphragm muscle.

Figure 3

mRNA content of atrophy markers muscle RING-finger protein-1 (MURF1) (A, n = 10), atrogin (B, n = 10), ubiquitin C (UBC) (C, n = 10), and growth arrest and DNA damage-inducible 45α (Gdd45a) (D, n = 10) was measured using quantitative PCR in the quadriceps of all groups. This was also completed in the diaphragm (E–H; n = 10). Results represent mean ± SD; 2-tailed t tests were used to determine the difference between PBS(2wk) versus C26(2wk) and PBS (4wk) versus C26(4wk). #P < 0.05 PBS(2wk) versus C26(2wk); ***P < 0.001 PBS(4wk) versus C26(4wk); ****P < 0.0001 PBS(4wk) versus C26(4wk).