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. 2023 Jan 10;8(1):e163855. doi: 10.1172/jci.insight.163855

Figure 2. Skeletal muscle mitochondrial inertia coexists with elevated ADP accumulation in muscle tissue during exercise.

Figure 2

(A) ADP levels in muscle tissue increases upon exercise onset. (B) ADP levels when PCr utilization reaches a new steady state at the onset of exercise. (C) Linear association between PCr on-kinetics and ADP levels when PCr reached a new steady state during exercise. [s], seconds; T2DM, patients with type 2 diabetes; OB, individuals with obesity; UT, lean untrained; T, trained. Circles in blue, T2DM (n = 8); circles in red, OB (n = 7); circles in green, UT (n = 8); circles in gray, T (n = 12). Data are shown as individual points and mean ± SEM. †P < 0.05 versus trained volunteers. Statistical test were 1-way ANOVA with Bonferroni post hoc correction and Pearson’s correlation.