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. Author manuscript; available in PMC: 2023 Mar 4.
Published in final edited form as: Curr Top Dev Biol. 2022 Mar 4;149:59–89. doi: 10.1016/bs.ctdb.2022.02.008

Fig. 2.

Fig. 2

Overview of the non-canonical Wnt-Fz/PCP pathway. Upper part: a simplified diagram of the interactions among the PCP core components, which results in the stable resolution and establishment of two complexes, the Fz-Fmi-Dsh-Dgo complex (presumed to be on the side of the Wnt ligand) and the Vang-Fmi-Pk complex. Lower part: Simplified schematic view of the Wnt/PCP signaling pathway downstream of the Fz-Dsh complex. The PCP pathway is activated when a Wnt ligand binds to a Frizzled (Fz/Fzd) receptor and induces a clustering of the core PCP protein to either the Vang/Vangl-Pk complex or Fz-Dsh-Dgo complex (upper part). Downstream activation of the PCP pathway is associated with Dsh/Dvl phosphorylation and its interactions with downstream effectors Rho and Rac, possibly also cdc42 (not shown), with for example RhoA then acting through either Rock or the JNK-type MAPK cascade, with the respective kinases regulating either the cytoskeleton assembly (Rock) or triggering the expression of the target genes in the nucleus (JNK) regulating cell fate decisions. See main text for details.