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. Author manuscript; available in PMC: 2023 Jan 23.

Published in final edited form as: Nature. 2022 Nov 16;611(7937):769–779. doi: 10.1038/s41586-022-05439-w

Extended Data Fig. 3: — a, Overview of ROSMAP cohorts on which lipidomic analysis was performed. Cartoons generated with BioRender b, Cohort clinicopathological characteristics. NFT = neurofibrillary tangles (p values calculated with Wilcoxon rank-sum test, two-sided). c, A single cholesterol ester (ChE) species passed quality control (see Methods) and showed significant (p<0.05, Wilcoxon rank-sum test, two-sided) differential concentration when comparing APOE3/3 vs APOE3/4 and APOE4/4-carriers stratified by pathology. ChE(18:1) indicates a ChE with carboxylate position 18 and one unsaturated fatty acid bond. d, Distribution of the concentration of ChE species from c) (p-value = 0.046, Wilcoxon rank-sum test, two-sided). Boxplots indicate median, 25^th and 75^th percentiles.

Extended Data Fig. 3: — a, Overview of ROSMAP cohorts on which lipidomic analysis was performed. Cartoons generated with BioRender b, Cohort clinicopathological characteristics. NFT = neurofibrillary tangles (p values calculated with Wilcoxon rank-sum test, two-sided). c, A single cholesterol ester (ChE) species passed quality control (see Methods) and showed significant (p<0.05, Wilcoxon rank-sum test, two-sided) differential concentration when comparing APOE3/3 vs APOE3/4 and APOE4/4-carriers stratified by pathology. ChE(18:1) indicates a ChE with carboxylate position 18 and one unsaturated fatty acid bond. d, Distribution of the concentration of ChE species from c) (p-value = 0.046, Wilcoxon rank-sum test, two-sided). Boxplots indicate median, 25^th and 75^th percentiles.