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. 2023 Jan 9;9:1090398. doi: 10.3389/fvets.2022.1090398

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Copyright © 2023 Cai, Shao, Wang, Xu, Ren, Fu and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DAE showed antiviral activity against PRV in mice. (A) The survival rate of mice in each group. (B) The viral load in the heart, kidney, liver, lung, and brain of mice in each group. The viral copy number in different organs was detected by FQ-PCR 76 h after PRV challenge. Histopathological sections of mouse brain were harvested from the uninfected control (C), infected control (D), and DAE-treated (E) mice, with hematoxylin-eosin staining (****P < 0.0001, ***P < 0.001, **P < 0.01).