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. 2023 Jan 10;8(1):e165207. doi: 10.1172/jci.insight.165207

Figure 5. C-10 ameliorates albuminuria and glomerulosclerosis in diabetic mice.

Figure 5

Type 2 diabetic db/db mice were treated with C-10 (2.5 mg/kg) for 8 weeks, starting at 10 weeks of age. (A) Urinary albumin/creatinine ratio (UCAR, left panel) and albuminuria (UAE) in 12-hour urine collection (right panel) were measured in control and diabetic mice treated with vehicle or C-10. (B) Periodic acid–Schiff–stained kidney images at ×200 (top) and ×400 (bottom) magnifications. Scale bars: 50 μm. (C and D) Glomerular area (C) and mesangial matrix fraction (D) in control and diabetic mice (n = 6 mice per group). *P < 0.05, **P < 0.01, ****P < 0.0001 compared with control db/m mice; #P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001 compared with vehicle-treated db/db mice by 1-way ANOVA with Bonferroni’s correction.