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. 2023 Jan 10;8(1):e165207. doi: 10.1172/jci.insight.165207

Figure 7. C-10 fails to protect against ADRN in Tyro3-knockout mice.

Figure 7

(A) Urinary albumin/creatinine ratio in Tyro3–wild-type (WT) and -knockout (KO) mice with ADRN treated with vehicle or C-10. (B) Twelve-hour albumin excretion in control and ADRN mice. (C) Periodic acid–Schiff–stained kidney images at ×200 (top) and ×400 (bottom) magnifications. Scale bars: 50 μm. (D) Glomerulosclerosis scoring in control and ADRN mice (n = 6 mice per group). *P < 0.05, ***P < 0.001, ****P < 0.0001 compared with WT ADR+Vehicle mice; #P < 0.05, ####P < 0.0001 compared with Tyro3-KO ADR+C-10 mice by 1-way ANOVA with Bonferroni’s correction.