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. 2023 Jan 10;8(1):e160578. doi: 10.1172/jci.insight.160578

Figure 6. Minocycline causes sustained shifts across taxa in the colonic bacteriome.

Figure 6

Female C57BL/6T specific pathogen–free (SPF) mice were administered vehicle control (VEH) or minocycline (MINO) from age 6 to 12 weeks; euthanized at (A–C) age 12 weeks and (D–F) age 18 weeks. Advanced 16S rDNA sequencing analysis of the colonic bacteriome; n = 5–6/group. Bacterial alpha diversity (Chao1 index) in (A) 12-week-old mice and (D) 18-week-old mice. Phyla relative abundance (%) in (B) 12-week-old mice and (E) 18-week-old mice. Genera relative abundance (%) in (C) 12-week-old mice and (F) 18-week-old mice. Unpaired 2-tailed t test with Holm-Šídák post hoc test in 12-week-old mice and 18-week-old mice; reported as mean ± SEM; *P < 0.05 vs. VEH, **P < 0.01 vs. VEH, ***P < 0.001 vs. VEH.