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. 2023 Jan 10;8(1):e160578. doi: 10.1172/jci.insight.160578

Figure 7. Minocycline causes persistent dysregulation of hepatic genes.

Figure 7

Female C57BL/6T specific pathogen–free (SPF) mice were administered vehicle control (VEH) or minocycline (MINO) from age 6 to 12 weeks; euthanized at (A) age 12 weeks and (B) age 18 weeks. (A) Liver RNA-Seq analysis in MINO- vs. VEH-treated female SPF mice at age 12 weeks; n = 4/group. Unpaired 2-tailed t test with P < 0.05; data presented as fold difference vs. VEH. (B) Liver RNA-Seq analysis in MINO- vs. VEH-treated female SPF mice at age 18 weeks; n = 4/group. Unpaired 2-tailed t test with P < 0.05; data presented as fold difference vs. VEH.