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. 2023 Jan 10;8(1):e160578. doi: 10.1172/jci.insight.160578

Figure 9. Minocycline upregulates conjugated bile acids in systemic circulation (serum).

Figure 9

Female C57BL/6T specific pathogen–free (SPF) mice were administered vehicle control (VEH) or minocycline (MINO) from age 6 to 12 weeks; euthanized at (A) age 12 weeks and (B) age 18 weeks. Mass spectrometry serum bile acid relative response analysis in MINO- versus VEH-treated female SPF mice at (A) age 12 weeks and (B) age 18 weeks; n = 5/group. Presented as fold difference versus VEH; unpaired t test; reported as mean ± SEM; *P < 0.05 vs. VEH, **P < 0.01 vs. VEH. TCDCA, taurochenodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; THDCA, taurohyodeoxycholic acid; THCA, taurohyocholic acid.