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. 2023 Jan 10;8(1):e158183. doi: 10.1172/jci.insight.158183

Figure 2. TMAO significantly reshaped transcriptome and upregulated 190 genes in human aortic endothelial cells (HAECs).

Figure 2

(A) HAECs were treated with TMAO (600 μM) for 18 hours, and RNAs were collected for RNA-Seq (n = 3). The volcano plots showed the differentially expressed genes with P < 0.05 and FC > 1.5. TMAO significantly upregulated 190 and downregulated 179 genes. (B) In total, 30% of TMAO-upregulated genes were upregulated in CKD renal specimens and 22.1% of TMAO-upregulated genes were upregulated in UT serum–treated HCAECs.