Table 1 .
Baseline characteristics according to rs2281279 genotype
| AA (n = 2438) | AG (n = 1642) | GG (n = 306) | All patients (n = 4386) | |
|---|---|---|---|---|
| Male sex (n, %) | 1687 (69%) | 1103 (67%) | 218 (72%) | 3008 (69%) |
| Age | 58.0 ± 12.1 | 57.5 ± 12.4 | 58.8 ± 11.5 | 57.9 ± 12.2 |
| Type of vascular disease | ||||
| Coronary heart disease (n, %) | 1106 (45%) | 733 (45%) | 147 (48%) | 1986 (45%) |
| Peripheral vascular disease (n, %) | 399 (16%) | 245 (15%) | 56 (18%) | 700 (16%) |
| Cerebrovascular disease (n, %) | 481 (20%) | 323 (20%) | 65 (21%) | 869 (20%) |
| Abdominal aortic aneurysm (n, %) | 166 (7%) | 117 (7%) | 15 (5%) | 298 (7%) |
| Diabetes mellitus type 2 (n, %) | 409 (17%) | 261 (16%) | 48 (16%) | 718 (16%) |
| Medication use | ||||
| Lipid-lowering treatment | 1368 (56%) | 891 (54%) | 180 (59%) | 2439 (56%) |
| Statins | 1350 (55%) | 885 (54%) | 176 (58%) | 2411 (55%) |
| High-intensity statins | 120 (5%) | 91 (6%) | 17 (6%) | 228 (5%) |
| Fibrates | 48 (2%) | 34 (2%) | 6 (2%) | 88 (2%) |
| Ezetimibe | 66 (3%) | 47 (3%) | 5 (2%) | 118 (3%) |
| Bile acid sequestrant | 1 (0%) | 2 (0%) | 0 (0%) | 4 (0%) |
| Antihypertensive treatment | 1631 (67%) | 1087 (66%) | 206 (67%) | 2924 (67%) |
| Platelet inhibitors | 1418 (58%) | 957 (58%) | 191 (62%) | 2566 (59%) |
| Current smoking | 776 (32%) | 534 (33%) | 101 (33%) | 1411 (32%) |
| Current alcohol consumption | 1215 (50%) | 790 (48%) | 157 (51%) | 2162 (49%) |
| BMI (kg/m2) | 26.8 ± 4.3 | 26.5 ± 4.2 | 26.9 ± 4.5 | 26.7 ± 4.3 |
| Waist circumference (cm) | 95 ± 13 | 94 ± 12 | 95 ± 13 | 94 ± 12 |
| Waist-to-hip ratio | 0.91 ± 0.08 | 0.90 ± 0.09 | 0.91 ± 0.09 | 0.91 ± 0.08 |
| Metabolic syndrome | 1226 (50%) | 817 (50%) | 168 (55%) | 2211 (50%) |
| SBP (mmHg) | 142 ± 21 | 141 ± 22 | 141 ± 22 | 141 ± 22 |
| DBP (mmHg) | 83 ± 12 | 83 ± 12 | 83 ± 12 | 83 ± 12 |
| Laboratory values | ||||
| Total cholesterol (mmol/L) | 5.17 ± 1.45 | 5.17 ± 1.36 | 5.19 ± 1.39 | 5.17 ± 1.41 |
| HDL-cholesterol (mmol/L) | 1.23 ± 0.39 | 1.24 ± 0.39 | 1.21 ± 0.33 | 1.23 ± 0.38 |
| Non-HDL-cholesterol (mmol/L) | 3.93 ± 1.46 | 3.94 ± 1.37 | 3.98 ± 1.38 | 3.94 ± 1.42 |
| LDL-cholesterol (mmol/L) | 3.14 ± 1.23 | 3.15 ± 1.20 | 3.19 ± 1.26 | 3.15 ± 1.22 |
| Triglycerides (mmol/L) | 1.40 (1.00–2.10) | 1.44 (1.00–2.10) | 1.41 (1.00–2.30) | 1.40 (1.00–2.10) |
| Insulin (mU/L) | 9 (6–14) | 9 (6–15) | 9 (6–15) | 9 (6–14) |
| Glucose (mmol/L) | 6.3 ± 2.1 | 6.3 ± 2.0 | 6.4 ± 1.8 | 6.3 ± 2.0 |
All data in n (%), mean with standard deviation or median (interquartile range).
HDL, high-density lipoprotein; LDL, low-density lipoprotein.