Table 4.

Summary of subgroup analyses based on stent variety.

Outcomes	Subgroup	Number of studies	Size of subgroup	Pooled rate (95% CI)	Heterogeneity between subgroups (P value)
Perioperative TIA	Wingspan	11	704	2.39% (1.21–3.86%)	P = 0.536
	Off-label SES	5	314	1.96% (0.52–4.05%)
Perioperative hemorrhagic stroke	Wingspan	34	2,832	1.75% (1.20–2.38%)	P = 0.051
	Off-label SES	18	1,133	0.89% (0.29–1.71%)
Perioperative ischemic stroke	Wingspan	34	2,832	3.26% (2.13–4.57%)	P = 0.547
	Off-label SES	18	1,133	2.81% (1.52–4.39%)
Perioperative stroke	Wingspan	36	3,063	6.49% (4.87–8.28%)	P = 0.063
	Off-label SES	18	1,133	4.34% (2.84–6.08%)
Perioperative death	Wingspan	36	3,063	0.41% (0.14–0.79%)	P = 0.230
	Off-label SES	18	1,070	0.12% (0.00–0.63%)
Perioperative stroke or death	Wingspan	36	3,063	6.71% (5.05–8.55%)	P = 0.051
	Off-label SES	18	1,133	4.38% (2.85–6.17%)
TIA beyond 30 days	Wingspan	24	1,918	1.56% (0.43–3.18%)	P = 0.289
	Off-label SES	14	665	0.54% (0.00–1.86%)
Ischemic stroke beyond 30 days	Wingspan	28	2,204	3.67% (2.82–4.61%)	P = 0.002
	Off-label SES	14	665	1.24% (0.35–2.48%)
Ischemic stroke or TIA beyond 30 days	Wingspan	29	2,335	5.32% (3.59–7.29%)	P = 0.018
	Off-label SES	15	839	2.29% (0.85–4.20%)
Death beyond 30 days	Wingspan	25	2,130	0.68% (0.27–1.21%)	p = 0.179
	Off-label SES	10	508	0.10% (0.00–0.90%)
Ischemic stroke or death beyond 30 days	Wingspan	24	2,080	4.35% (2.76–6.23%)	P = 0.028
	Off-label SES	10	508	1.66% (0.42–3.44%)
ISR	Wingspan	26	1,289	15.73% (11.31–20.66%)	P = 0.036
	Off-label SES	15	780	8.84% (4.80–13.79%)

The off-label SES subgroup had better long-term outcomes than the Wingspan subgroup in terms of long-term ischemic stroke beyond 30 days, ischemic stroke or TIA beyond 30 days, ischemic stroke or death beyond 30 days, and ISR (P value < 0.05).