Table 5.

Univariate meta-regression analyses based on publication time.

Outcomes	Number of studies	Size of outcomes	Exp(b)	(95% CI)	p value
Perioperative TIA	15	942	1.004	0.8710–1.1573	0.953
Perioperative hemorrhagic stroke	51	3,957	0.9886	0.9237–1.0580	0.735
Perioperative ischemic stroke	50	3,821	0.9793	0.9146–1.0487	0.542
Perioperative stroke	52	4,052	0.9643	0.9037–1.0289	0.266
perioperative death	54	4,133	0.991	0.9292–1.0570	0.780
Perioperative stroke or death	58	4,632	0.9527	0.8966–1.0122	0.115
TIA beyond 30 days	37	2523	1.0011	0.9227–1.0861	0.979
Ischemic stroke beyond 30 days	41	2,809	1.0083	0.9324–1.0904	0.831
Ischemic stroke or TIA beyond 30 days	43	3,114	0.9998	0.9295–1.0754	0.996
Death beyond 30 days	34	2,578	1.0126	0.9330–1.0991	0.757
Ischemic stroke or death beyond 30 days	33	2,528	1.0217	0.9408–1.1096	0.599
ISR	40	2,009	0.9412	0.8585–1.0319	0.19
Ischemic stroke beyond 30 days through 1 year	13	1,853	0.9746	0.8708–1.0908	0.625

Univariate meta-regression analysis was adjusted by publication time (2005–2013 subgroup or 2014–2022 subgroup).