Table 1.
Clinical features of DN patients with different serum FXIII-A levels at baseline.
| Parameter |
High FXIII-A group (n = 35) |
Normal FXIII-A group (n = 60) |
P-value |
|---|---|---|---|
| Age (years) | 52.2 ± 6.96 | 54.07 ± 9.16 | 0.300 |
| Gender (M/F) | 26/9 | 46/14 | 0.808 |
| FXIII-A (pg/ml) | 777.63 ± 89.20 | 549.60 ± 87.66 | 0.000 |
| TM (ng/ml) | 7.62 ± 1.48 | 4.89 ± 0.91 | 0.000 |
| Fibrinogen (g/l) | 4.69 ± 1.17 | 4.05 ± 1.18 | 0.012 |
| Diabetes duration (Months) | 103.54 ± 61.95 | 108.13 ± 72.08 | 0.754 |
| Diabetic retinopathy (%) | 42.3(15) | 38.3(23) | 0.671 |
| Hemoglobin (g/l) | 108.17 ± 17.57 | 118.55 ± 20.27 | 0.013 |
| BMI (kg/m2) | 25.10 ± 2.74 | 24.56 ± 3.35 | 0.417 |
| Smoking (%) | 57.1(20) | 43.3(26) | 0.209 |
| SBP (mmHg) | 150.37 ± 24.71 | 146.63 ± 24.93 | 0.481 |
| DBP (mmHg) | 85.09 ± 12.24 | 83.57 ± 12.00 | 0.556 |
| Serum creatine (mg/dl) | 142.11 ± 53.32 | 110.44 ± 38.17 | 0.001 |
| eGFR (>15 ml/min/1.73 m2) | 55.63 ± 30.76 | 70.98 ± 30.30 | 0.020 |
| Initial proteinuria (g/d) | 5.44 ± 3.10 | 4.63 ± 3.97 | 0.302 |
| HbA1c (%) | 7.91 ± 2.66 | 8.14 ± 2.24 | 0.648 |
| Total cholesterol (mmol/l) | 2.59 ± 2.19 | 2.18 ± 1.62 | 0.295 |
| Triglyceride (mmol/l) | 3.12 ± 1.14 | 2.86 ± 1.26 | 0.318 |
| RAAS inhibitor (%) | 4/31 | 11/49 | 0.561 |
| Progressed to ESKD (%) | 40 | 16.7 | 0.021 |
Data are presented as the mean ± standard SBP, Systolic blood pressure; DBP, Diastolic blood pressure; e-GFR, estimated glomerular filtration rate; BMI, Body mass index; HbA1c, glycosylated hemoglobin; RAAS, Renin-angiotensin-aldosterone system; ESKD, end-stage kidney disease.