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. 2023 Jan 9;13:974793. doi: 10.3389/fimmu.2022.974793

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Copyright © 2023 Hua, He, Chen, He, Wu, Ye, Zhou, Li, Ding, Zhong, Teng, Jiang and Sheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical response of an ICIs-treated NRKT fusion MSI-H CRC patient. (A) Diagram of the course of disease management, showing different treatment regimens prescribed. (B) The molecular diagnosis of this case. (C) IHC staining of PD-L1 expressions in tumor proportion score (TPS), combined positive score (CPS), positive control (PC), and negative control (NC). (D) CT evaluation and HE images of the patient at the first (upper) and second (lower) surgical timepoint. (E) Comparison of MLH1 methylation levels between NRKT fusion MSI-H tumor tissue and non-tumor tissue. T, tumor tissue; N, non-tumor tissue.