TABLE 3.
Studies showing that reduced response to adrenergic stimulation is correlated with cardiac adverse outcome in patients with idiopathic DCM.
Paper | Non-responders, responders | Outcome measured | Follow up time | Adverse events (responders) | Adverse events (non-responders) |
(84) | 38, 33 | Cardiac mortality | 60 mo | 9% | 42% |
(85) | 11, 10 | Δ LVEF, Δ LV sphericity | 6 mo | 0% | 45% |
(86) | 11, 7 | Δ LVEF improvement | 15 mo | 0% | 36% |
(87) | 83, 103 | Cardiac mortality | 15 mo | 3% | 25% |
(88) | 89, 43 | Mortality and/or hospitalization | 40 mo | 16% | 49% |
(89) | 13, 24 | Cardiac mortality | 60 mo | 34% | 76% |
(90) | 15, 28 | Mortality and/or hospitalization | 23–67 mo | 11% | 67% |
Data partially based on Waddington (81).