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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Addict Biol. 2022 May;27(3):e13162. doi: 10.1111/adb.13162

TABLE 3.

Genes with cis-eQTL and genetic correlation to cocaine infusions

Gene Tissue Region Tissue Group IVSA Days Correlation to Cocaine Infusions (r, p) Correlation to Saline Infusions (r, p) ePheWAS Results
Chromosome 14 QTL (55088089–57688089 Mb)
Gjb6 mFC Cocaine 7–8 0.53, 0.000458* 0.28, 0.088546 none
5–6 0.56, 0.000184* 0.35, 0.028524
Difference Score 7–8 0.6, 0.000051* 0.45, 0.003659*
5–6 0.55, 0.000288* 0.53, 0.000549*
NAc Difference Score 7–8 0.54, 0.000385* 0.17, 0.298484
5–6 0.4, 0.012292* 0.26, 0.108479
Mphosph8 mFC Saline 7–8 −0.52, 0.000766* −0.56, 0.000188* none
5–6 −0.53, 0.000492* −0.56, 0.000194*
NAc Difference Score 7–8 0.53, 0.000544* 0.44, 0.004742*
5–6 0.53, 0.000543* 0.54, 0.00035*
Saline 7–8 −0.52, 0.000687* −0.53, 0.000473*
5–6 −0.52, 0.000609* −0.6, 0.000053*
Nop9 mFC Cocaine 7–8 0.44, 0.005564* 0.32, 0.046507 BXD Epoch of production (GN12689)
NAc Difference Score 7–8 0.38, 0.016632* 0.25, 0.117628
Zmym5 mFC Difference Score 7–8 0.45, 0.003662* 0.3, 0.059557 none
5–6 0.43, 0.006051* 0.33, 0.039581
Saline 7–8 −0.55, 0.000282* −0.2, 0.219552
5–6 −0.53, 0.000578* −0.43, 0.006124*
NAc Difference Score 7–8 0.46, 0.002915* 0.48, 0.00211*
5–6 0.47, 0.002322* 0.55, 0.000277*
Saline 7–8 −0.51, 0.000927* −0.42, 0.007298*
5–6 −0.49, 0.001555* −0.53, 0.000545*
Chromosome 3 QTL (50406218–53006218 Mb)
Gm20750 mFC Cocaine 5–6 −0.34, 0.031558* −0.37, 0.021814 none
7–8 −0.34, 0.033746* −0.37, 0.020983
NAc Difference Score 5–6 0.34, 0.033408* 0.42, 0.00828*
7–8 0.34, 0.033736* 0.4, 0.012112*
Saline 7–8 −0.44, 0.005551* −0.22, 0.171097
Ndufc1 mFC Cocaine 9–1 0.44, 0.005277* 0.21, 0.193813 BXD Epoch of production (GN12689)
5–6 0.42, 0.007577* 0.22, 0.173639
7–8 0.47, 0.00235* 0.21, 0.194256
Difference Score 9–1 0.55, 0.000257* 0.27, 0.095173
5–6 0.51, 0.000942* 0.36, 0.023188
7–8 0.58, 0.000126* 0.31, 0.053681
NAc Cocaine 9–1 0.51, 0.000831* 0.23, 0.161079
5–6 0.53, 0.000569* 0.36, 0.022425*
7–8 0.58, 0.000108* 0.3, 0.06051
Difference Score 9–1 0.5, 0.001244* 0.23, 0.161079
5–6 0.44, 0.004634* 0.33, 0.041757*
7–8 0.52, 0.000658* 0.29, 0.070091
Noct NAc Cocaine 9–1 0.35, 0.027096* −0.1, 0.564003 Dock1 (D2 medium spiny neuron expression signature)(GN15553), D1 expression (GN15185), Dopamine receptor ratio (Drd1 to Drd2)(GN15554), Tibia gracility index (GN18419), Ebf1 (D1 medium spiny neuron expression signature)(GN15552)
5–6 0.41, 0.010415* 0.34, 0.033079*
7–8 0.44, 0.005052* 0.26, 0.106702
Difference Score 5–6 0.31, 0.054767* 0.23, 0.165352
7–8 0.32, 0.050066* 0.23, 0.155525
Setd7 mFC Cocaine 5–6 −0.39, 0.013922* −0.26, 0.114428 Activity in closed quadrants using an elevated zero maze(GN12354), BXD Epoch of production (GN12689)
7–8 −0.37, 0.021821* −0.15, 0.358531
NAc Difference Score 9–1 0.42, 0.007962* 0.45, 0.004333*
5–6 0.53, 0.000501* 0.47, 0.002436*
7–8 0.54, 0.000369* 0.35, 0.026742*
Chromosome 3 suggestive QTL (35474653–38074653 Mb)
4932438A13Rik NAc Difference Score 5–6 0.41, 0.009087* 0.58, 0.000094* none
mFC Saline 5–6 −0.39, 0.015236* −0.51, 0.000796*
8430422M14Rik NAc Difference Score 5–6 0.4, 0.012174* 0.17, 0.30793 none
D3Ertd254e mFC Cocaine 5–6 −0.47, 0.00241* −0.52, 0.000769* none
Saline 5–6 −0.49, 0.001601* −0.58, 0.000123*
NAc Saline 5–6 −0.47, 0.002594* −0.68, 0.000002*
Exosc9 mFC Difference Score 5–6 0.4, 0.012199* 0.36, 0.025473 none
NAc 5–6 0.46, 0.003264* 0.38, 0.015552*
Spata5 mFC Difference Score 5–6 0.41, 0.008782* 0.41, 0.009916 D1 expression(GN15185), Dopamine receptor ratio (Drd1 to Drd2)(GN15554), Ebf1 (D1 medium spiny neuron expression signature)(GN15552)
Saline 5–6 −0.48, 0.002111* 0.27, 0.100151
NAc Difference Score 5–6 0.5, 0.001247* 0.62, 0.000031*

Abbreviations: IVSA, intravenous self-administration; mFC, medial frontal cortex; NAc, nucleus accumben; QTL, quantitative trait loci.

*

indicates significance after correction for multiple comparisons.