A: schematic time line and description of the experimental design, animal numbers per group, mortality rate, and end points measured. B: physiological parameters of the study groups. BBB, blood brain barrier; DFX, deferoxamine; HFD, high-fat diet; IHC, immunohistochemistry; MCAO, middle cerebral artery occlusion; NVU, neurovascular unit; STZ, streptozotocin.