Table 2: Combination therapies and BRAID analysis.

The variable κ represents a quantitative synergy value where κ < 0 implies antagonism, κ = 0 implies additivity, and κ > 0 implies synergy. As an additional reference, “strong synergy” corresponds to κ = 2.5, “mild synergy” corresponds to κ = 1, “mild antagonism” corresponds to κ = −0.66, and “strong antagonism” corresponds to κ = −1.

Compound 1	Compound 2	Κ (average of 4 experiments)
Pyronaridine	Crizotinib	−0.640
Pyronaridine	Etoposide	−0.746
Crizotinib	Etoposide	3.46