Table 3.
Minimum biofilm eradication concentration (MBEC) of amikacin and thymol-loaded PLGA and the fractional inhibitory concentration index (FICI) of combination against S. enterica serovars.
| Isolates | MBEC (μg/mL) | MBEC reduction fold | FICI (int.) | ||||
|---|---|---|---|---|---|---|---|
| Alone | Combined | ||||||
| Ami | TH-NPs | Ami | Thy | Ami | TH-NPs | ||
| S. Typhi ATCC 6539 | 128 | 64 | 2 | 8 | 64 | 8 | 0.14 (S) |
| S. Typhi | 128 | 64 | 1 | 16 | 128 | 4 | 0.26 (S) |
| S. Enteritidis | 128 | 128 | 4 | 4 | 32 | 32 | 0.06 (S) |
| S. Typhimurium | 64 | 64 | 1 | 16 | 64 | 4 | 0.27 (S) |
| S. Choleraesuis | 64 | 128 | 0,5 | 16 | 128 | 8 | 0.13 (S) |
MBEC: minimum biofilm eradication concentration; Ami: amikacin; TH-NPs: thymol-loaded PLGA nanoparticles; FICI: fractional inhibitory index; INT: interpretation; S: synergy.