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. 2022 Dec 12;7(1):24–37. doi: 10.1038/s41551-022-00969-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a. Transgene marker expression of iCAR-T_CTL and CAR-o/e-iCAR-T_CTL b. Surface antigen profiles of iCAR-T_CTL and CAR-o/e-iCAR-T_CTL. iCAR-T_CTL and CAR-o/e-iCAR-T_CTL were evaluated using surface antigen expression related to T/NK linage, naïve/memory, and exhaustion phenotype. c-d. Detection of phosphorylated ERK (pERK) in iCAR-T_CTL and CAR-o/e-iCAR-T_CTL 60 min after co-culturing with irradiated SK-Hep-GPC3 e. In vitro cytotoxic assays of iCAR-T_CTL and CAR-o/e-iCAR-T_CTL against JHH7 and SK-Hep-GPC3. n = 4, mean ± SD. f. proliferation assay of iCAR-T_CTL and CAR-o/e-iCAR-T_CTL. g. Cytokine production of iCAR-T_CTL and CAR-o/e-iCAR-T_CTL cells 48 h after co-culturing with irradiated SK-Hep-GPC3 (n = 4, mean ± SEM). Student’s t-test.