Extended Data Fig. 9. DGK-dKO-iCAR-TILC have similar tumor suppressive function DGK-dKO-iCAR-TCTL in KOC7c pre-inoculated peritoneal dissemination mouse model.
a-d. NSG mice were injected intraperitoneally with 5 × 105 KOC7c cells expressing luciferase. From the third day after the ovarian cancer inoculation, 5 × 106 DGKdKO-iCAR-TCTL and DGKdKO-iCAR-TILC were injected intraperitoneally twice a week for 2 weeks (n = 5 for each group). In vivo bioluminescence imaging of luciferase-labeled KOC7c in NSG mice treated with DGKdKO-iCAR-TCTL and DGKdKO-iCAR-TILC (b). Change in the total body flux as total tumor volume (mean ± SEM) (c) and survival (d) were evaluated at the indicated time points after the injection. Log-rank test with Bonferroni multiple comparisons test. SEM, standard error of the mean.