Fig. 6. Combinatorial signal enhanced iCAR-TCTL anti-tumour function.
a, Treatment schedule of the liver cancer subcutaneous (s.c.) xenograft model. NSG mice were injected intraperitoneally with 2 × 105 JHH7 cells 3 days before treatment. In total, 1 × 106 iCAR-TCTL-mbIL15tg, DGK-dKO-iCAR-TCTL-mbIL15tg or pCAR-TCTL-mbIL15tg were injected intravenously on day 0 (n = 5 for each group). b Volume of inoculated JHH7 at indicated timepoints in individual mice treated with indicated test cells. c, Volume of inoculated JHH7 at indicated timepoints. Mean tumour size ± s.e.m. (n = 5 of each group), by two-way ANOVA. d, Survival of treated mice at indicated timepoints after injection. log-rank test with Benjamini–Hochberg multiple comparisons test.