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. 2022 Dec 12;7(1):24–37. doi: 10.1038/s41551-022-00969-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a. CD19 expression on iPSCs, hematopoietic progenitor cells, and T-cell lineages in the differentiation process. The CD19 expression on PBMCs is indicated as a reference (right). b. Hematopoietic progenitor cells derived from inducible 1928z CAR-transduced T-iPSCs were divided into two groups and subsequently differentiated into immature iCAR-T in the presence (2 μg/mL) or absence of doxycycline (Dox). Surface antigen expression of CD3, CD45, CD5, CD7, CD4, CD8a from the two groups is shown. HSPC, hematopoietic stem progenitor cells. c,d. Inducible 1928z CAR-transduced T-iPSCs were differentiated into immature iCAR-T cells without Dox and cultured for 1 more week in the presence or absence of Dox. The expression profile of CD4 and CD8β (c) and o NK-cell-related surface antigens (d) are indicated. N = 3, mean ± SEM, statistical tests. Two-sided Student’s t test. MFI, mean fluorescence intensity, SEM, standard error of the mean.