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. 2022 Dec 12;7(1):24–37. doi: 10.1038/s41551-022-00969-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a. Representative flow cytometry plots showing T cell lineage-related surface antigen profiles of iCAR-T_CTL, iCAR-T_IL, and pCAR-T_CTL. b. Flow cytometry plots showing the expression of surface markers associated with the NK cell lineage on iCAR-T_CTL, iCAR-T_ILC, and pCAR-T_CTL. c. Volcano plot of DEGs between iCAR-T_CTL and iCAR-T_ILC. d. The list of upregulated genes in iCAR-T_CTL. Pathway and process enrichment analysis was performed using online tools in Metascape (http://metascape.org/)⁴⁹. e. Cytokine production of iCAR-T_CTL, iCAR-T_ILC, and pCAR-T_CTL 48 h after co-culturing with irradiated SK-Hep-GPC3 (n = 3, mean ± SEM). ns, not significant. One-way ANOVA with Tukey’s multiple comparisons test.