Table 2:
Cox Regression Model showing the association of baseline frailty status on overall survival among older adults with GI malignancies.
| Variable | Hazards Ratio | 95% CI | P value |
|---|---|---|---|
|
| |||
| Frailty Category | |||
| - Robust | Ref | - | |
| - Pre-frail | 1.16 | 0.81–1.65 | .42 |
| - Frail | 1.83 | 1.34–2.49 | <.001 |
|
| |||
| Age category | |||
| - 60–65 y | Ref | - | |
| -66–70 y | 0.85 | 0.59–1.22 | .39 |
| - >70 y | R1.06 | 0.79–1.43 | .70 |
|
| |||
| Sex | .28 | ||
| - Female | Ref | - | |
| - Male | 1.15 | 0.89–1.50 | |
|
| |||
| Race | |||
| - White/Caucasian | Ref | - | |
| - Othersa | 0.73 | 0.54–1.00 | .05 |
|
| |||
| Cancer Stage | |||
| - Stage I-II | Ref | - | |
| - Stage III-IV | 1.38 | 1.00–1.89 | .05 |
|
| |||
| Cancer Type | |||
| - Colorectal | Ref | - | |
| - Pancreatic | 2.03 | 1.45–2.86 | <.001 |
| - Other GI cancersb | 1.12 | 0.80–1.56 | .51 |
|
| |||
| Line of Therapy | |||
| - 1st line | Ref | ||
| - 2nd line and beyond | 1.36 | 0.95–1.94 | .09 |
GI, gastrointestinal; CI, confidence interval
a
Other race includes Black (146) and Hispanics (12).
b
Other GI includes Hepatobiliary (104), Gastroesophageal (60), Anal cancer (13), Appendiceal Cancer (7), Gastrointestinal stromal tumor (17), Neuroendocrine carcinoma (51), and GI not otherwise specified (5)