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. 2023 Jan 23;14:376. doi: 10.1038/s41467-022-35726-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Cryo-EM density maps and models of the M2R-GoA complex bound to ACh in S1 (a) and S2 states (b). c, d Cryo-EM density maps and models of the M2R-GoA complex bound to ACh and the PAM LY2119620 in S1 (c) and S2 (d) states. The maps and models are colored according to polypeptide chains. The map densities of ACh (shown as sticks) are depicted as gray meshes.