Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 23;14:376. doi: 10.1038/s41467-022-35726-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a Comparison of the P^5.50-V^3.40-F^6.44 core triad and conserved side-chains R121^3.50, Y206^5.58 and Y440^7.53 in the intracellular domain of S1 and S2 states with or without LY2119620. The ε-¹³CH₃ of M202^5.54 is shown as a sphere. b Comparison of the intracellular surfaces. c, d The HSQC spectra of M202^5.54 in apo, ACh-bound and ACh/LY2119620-bound, as well as Ixo-bound and Ixo/LY2119620-bound states. Color code: gray (apo), light teal (ACh), purple (ACh/LY2119620), blue (Ixo), light green (Ixo/LY2119620). e Comparison of conformations of intracellular residues R121^3.50, Y206^5.58 and Y440^7.53 in G-protein and β-arrestin-1 coupled structures. PDB code: Ixo-M2R-β-arrestin-1 (6U1N), Ixo-M2R-GoA (6OIK). f Effects of β-arrestin-1 and miniGαo on the HSQC spectra of M202^5.54. Color code: blue (Ixo), magenta (Ixo/phosphorylation), red (Ixo/miniGαo), green (Ixo/phosphorylation/β-arrestin-1).