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. 2023 Jan 23;14:366. doi: 10.1038/s41467-023-36014-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Relative DRG subtype proportions across all species (computed in lumbar levels only). b Heatmap of conserved genes and species-specific genes by DRG subtypes from panel (c). c Customized UpSet plot showing a number of conserved and species-specific genes across datasets for each of the major sensory neuron subtypes, as indicated above each plot. Total number of genes that are unique to one species (one colored box per row), or shared across multiple species (multiple colored boxes per row), are indicated to the right of each row. d Plot indicating evolutionary distance (x-axis; icons at top) and transcriptional correlation (y-axis) for each sensory neuron subtype (indicated by colors) between humans and other preclinical species. Correlation values are indicated by colored circles; the values across all species are connected with a solid line. e Heatmap indicating normalized expression levels of genes associated with pain perception in each neuronal subtype. f Number of genes with a divergent or non-divergent expression between mouse and human DRGs indicated by gene ontology(GO) annotation category. Numeric numbers on each bar represent the total number of expressed genes in a given GO category. g Number of divergently expressed genes between mouse and human samples from panel (f), colored by DRG class (left) or subtype (right). NP denotes non-peptidergic; PEP denotes peptidergic for (a–g). M denotes mouse, G denotes guinea pig, C denotes cynomolgus monkey, and H denotes human for (a–c). Species icons in b and d were created with BioRender.com.