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. 2023 Jan 23;13:1273. doi: 10.1038/s41598-023-27375-z

Figure 1.

Figure 1

OTX-015 inhibits the viability of D458 and D283 MB cell lines. D458 (red) and D283 (black) were treated with different concentrations of OTX-015 spanning from 0 to 10 µM as indicated for (A) 24 and (B) 48 h. Statistical significance of cell viability inhibition was performed using one-way ANOVA with **; *** and **** indicating p < 0.05, < 0.005 and < 0.0001, respectively. (C) Representative Western blot showing MYC downregulation upon treatment with OTX-015 (2.5, 5.0, 7.5, and 10.0 µM) for 24 h. Bold numbers indicate percentage reduction of normalised c-MYC (c-MYC/β-Actin) versus control (DMSO). Original Western blots are presented in Supplementary Fig. 1.