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. 2023 Jan 23;14:373. doi: 10.1038/s41467-023-36054-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic drawing representing the cell populations in the adult SEZ neurogenic lineage (qNSC: quiescent neural stem cells; pNSC: primed NSC; aNSC: activated NSC; NPC: neural progenitor cell; ENB: early neuroblast; LNB: late neuroblast). Adult NSC can be cultured and expanded in vitro as clonal aggregates, neurospheres. Cell cycle entry and exit points along the lineage are highlighted. b Scatterplot comparing differential expression (DE) data from isolated qNSC vs. aNSC populations¹² with translation efficiency data from OB NBs¹⁷. c Gene Ontology (GO) enrichment analysis of genes that define the qNSC and aNSC signature and are subjected to translational repression during lineage differentiation. d Heatmap showing the expression pattern of different families of RNA-binding proteins (RBPs) in isolated SEZ populations¹². e Ridgeplot showing average expression of Cluster 1 RBPs in SEZ populations. f Cluster 1 RBP motive analysis in qNSC-signature genes that are translationally repressed during neuroblast differentiation. Graph shows the percentage of 3’UTR sequences that include the RBP motive compared to a set control 3’UTR.