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. 2023 Jan 23;14:167. doi: 10.1038/s41467-023-35804-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Mice fed a HFD for 16 weeks underwent Ripk3 knockdown (R-KD) and partial hepatectomy. a Haematoxylin-eosin staining. Scale bar, 50 μm. Asterisks indicate hepatocellular death foci. b Plasma ALT levels. c TUNEL staining. Scale bar, 50 μm. Arrowheads indicate solitary dead hepatocytes. Asterisks indicate hepatocellular death foci. Arrows indicate perifocal dead hepatocytes. d Number of TUNEL⁺ hepatocytes defined as described. e TUNEL/Cl-CASP3 double staining (left). Cl-CASP3⁺ or Cl-CASP3⁻ hepatocytes as a percentage of TUNEL⁺ hepatocytes (right). f Immunoblot analysis. Data are presented as the mean values ± SEM. [n = 6/group, biologically independent samples]. Statistics: one-way repeated-measures ANOVA followed by Bonferroni’s multiple comparisons test (b), two-tailed Student’s t test (d, e). CTRL, control; T, time effect; G, group effect; T×G, time and group interaction. Source data are provided as a Source Data file.