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. 2023 Jan 23;14:167. doi: 10.1038/s41467-023-35804-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — A-KO mice and littermates (CTRL) were fed an MCD for 6 weeks. a Sirius red staining. Scale bar, 50 μm. b Plasma ALT levels at the indicated time points. c TUNEL staining (left). Scale bar, 50 μm. Arrowheads indicate TUNEL⁺ hepatocytes. Number of TUNEL⁺ hepatocytes (right). d, e Quantitative PCR analysis of genes related to fibrosis (d) and the eIF2α signalling pathway and necroptosis (e). f Immunoblot analysis. g Quantitative PCR analysis of genes related to ferroptosis. h Hepatic MDA levels. Data are presented as the mean values ± SEM. [n = 6/group, biologically independent samples]. Statistics: one-way repeated-measures ANOVA followed by Bonferroni’s multiple comparisons test (b), two-tailed Student’s t test (c–e, g, h). G, group effect; T, time effect. Source data are provided as a Source Data file.