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. 2023 Jan 23;9:23. doi: 10.1038/s41420-023-01337-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Neddylation is a process that conjugates NEDD8 to cullins or non-cullin substrates via a three-step reaction, catalyzed by NEDD8-activating enzyme E1 (a heterodimer of NAE1 and UBA3), NEDD8-conjugating enzyme E2 (UBE2M or UBE2F) and substrate-specific NEDD8-E3 ligases (e.g., RBX1 and RBX2). MLN4924: an inhibitor of UBA3; N8: neuronal precursor cell-expressed developmentally downregulated protein 8.