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. 2022 Dec 21;28:100568. doi: 10.1016/j.bbih.2022.100568

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© 2022 Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1 — The neuroinflammatory evolution in aging PolyI:C mice: (A) Timeline of the experimental procedure and PolyI:C injections. (B) qPCR quantification of pro-inflammatory cytokines (IL-6, IL-1beta, INF-gamma) in the hippocampus after the PolyI:C treatment. Transcript analysis for (C) neuronal (GRIN), (D) microglia (Iba1) and (E) astroglial (GFAP) markers; represented as mean ± SEM, n = 4–5 mice per age and treatment. *p < 0.05, **p < 0.005, #p = 0.07. Statistical significance based on two-way ANOVA with Bonferroni post hoc analysis. (F) Correlation matrix indicates the associations between time series of Grin1, Iba1, GFAP with the examined cytokines. Highlighted squares with significant correlation. GD = gestational day, BD = birth day.