TABLE 3.
Effects of active PcrV protein immunization plus passive antitoxin A treatment on mortality in burned mice infected with the highly toxigenic P. aeruginosa strain 1071
| Treatment | No. of dead mice/total no. of mice on daya:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 8 | 9 | 10 | |
| Mock (untreated control) | 0/10 | 7/10 | 8/10 | 8/10 | 8/10 | 8/10 | 8/10 | 8/10 |
| Mock + antitoxin | 0/10 | 3/10 | 5/10 | 6/10 | 6/10 | 6/10 | 6/10 | 6/10 |
| PcrV | 0/10 | 1/10 | 3/10 | 4/10 | 5/10 | 5/10 | 5/10 | 5/10 |
| PcrV + antitoxin | 0/10 | 0/10∗ | 1/10 | 2/10 | 2/10 | 4/10 | 4/10 | 4/10 |
a
Overall significant differences in mortality were determined at day 2, followed by pairwise chi-square comparisons. Because the four groups allowed six possible pairwise comparisons, our required level of significance was adjusted to P of <0.0083 (∗) for these comparisons.