Table 3.
Clinical trials that investigated the effects of HT in humans.
| Study (year) | Sample (size) | Treatment Group (size) | Methodology | Outcomes |
|---|---|---|---|---|
| [36] | Eligible human patients (n = 40) | Placebo group Aquilea cholesterol group |
2 weeks of a healthy diet. Both placebo and nutraceutical were taken daily before the main meal during 90 days. |
Nutraceutical treatment reduced LDL col, ApoB and CRP levels |
| [37] | Eligible human patients (n = 84) | Placebo Oral supplementation group |
2 treatment sequences including oral supplementation or placebo for 8 weeks, followed by a 4-week wash-out interval and then a crossover. | After oral supplementation, SBP and DBP were reduced while FMD increased. ox-LDL levels were reduced too. |
| [7] | Eligible human patients (n = 32) | Water (control) WW WW + Tyr |
3 intervention periods during 4 weeks preceded by 3 wash-out periods. | After WW + Tyr period increase HDL and AT III while it Hcy decreases. |
| [38] | Eligible human patients (n = 20) | Placebo group Olp group |
Participants in both groups consume 4 tablets/day (30 mg/day HT). A wash-out period of 2 months and then a crossover. |
HT treatment improved TC and LDL cholesterol levels. |
| [39] | Eligible human patients (n = 30) | Control group Extract group |
For 8 weeks 1 group consumed placebo and the other an extract from OO and AS | EG decreased oxLDL levels and it improved oxLDL/LDL-col ratio. |
| [40] | Eligible human patients (n = 84) | SAx supplement Placebo |
3 capsules/day of the assigned product during 20 weeks separated into 8 weeks of treatment (supplement or placebo) by a washout period of 4 weeks. | Supplementation decreased LDL and TG levels while it increases HDL levels. |
Abbreviations: ApoB: Human apolipoprotein B; AS: Almond skin; AT III: antithrombin III; CRP: C-reactive protein; DBP: Diastolic blood pressure; EG: Extract group; FMD: Flow mediated dilatation; Hcy: Homocysteine; HDL: High density lipoproteins; LDL: Low density lipoproteins; Olp: Olive pâté; SBP: Systolic blood pressure; TC: Total cholesterol; TG: triglycerides; Tyr: Tyrosol; OO: Olive oil; oxLDL: oxidized LDL; WW: White wine.