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. 2023 Jan 10;13:1091018. doi: 10.3389/fphar.2022.1091018

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Copyright © 2023 Zhou and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Collection of key prognostic genes. (A) Protein-protein interaction network diagram of 18 target genes (B) MCC method was performed to identify the key Top 5 molecular in the protein-protein Interaction network. (C,D) the expression level of 5 key prognostic genes in normal tissues and tumor tissues (E–G) the Correlation between 5 key prognostic genes and immune scores. (H) qPCR assay detect the expression of LEF1. (I) Transwell assay detect the invasion of the A549 cell line after knockdown LEF1. (J) CCK-8 assay detect the proliferation of the A549 cell line after knockdown LEF1.