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. 2023 Jan 10;13:1063326. doi: 10.3389/fphys.2022.1063326

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Copyright © 2023 Huo, Grotle, McCuller, Samora, Stanhope, Havel, Harrison and Stone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The change in MAP (A) and HR (C) from baseline were averaged second by second to show the temporal changes during 30 s of tendon stretch in male T2DM rats and healthy, age-matched controls. ΔBPi (B) and ΔHRi (D) were then calculated over the 30 s of contraction to determine the difference between T2DM rats and healthy, age-matched controls at all stages. The ΔBPi and ΔHRi were greater in the T2DM rats compared to healthy, age-matched controls during the early onset stage of T2DM. Two-way ANOVA with Holm-Sidak’s post hoc comparisons (*) p < 0.05 indicates significant increase relative to age-matched control.