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. 2023 Jan 10;13:1066713. doi: 10.3389/fphar.2022.1066713

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Copyright © 2023 Wan, Wu, Li and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic timeline of this research. Pregnant rats received 2-h exposure of 3.5% sevoflurane or air in the day 0 of gestation (G0). Thirty min prior to sevoflurane or air exposure, rats were subjected to intraperitoneal injection with Rimonabant (RIM, 1 mg/kg) or vehicle (Veh). Brain tissues were harvested from fetal rats at 6, 12, or 24 h subsequent to sevoflurane exposure. The offspring rats in each group were employed for neurobehavioral tests and Morris water maze (MWM) tests during P3–33. Next, the hippocampus was harvested 1 h after MWM test.