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. 2023 Jan 10;13:1066713. doi: 10.3389/fphar.2022.1066713

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Copyright © 2023 Wan, Wu, Li and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maternal sevoflurane exposure caused dysfunction in neurobehaviors and cognitive memory in neonatal rats. Neurobehavioral tests (n = 12 per group) were performed during P3–13 and included surface righting reflex (A), negative geotaxis reflex (B), forelimb grip test (C), cliff avoidance test (D), and sensory reflexes (E). The MWM tests (n = 12 per group) were carried out during P28–33. Escape latency (F), the times of crossing the platform (G), and time spent in each quadrant (H) were recorded. Data are depicted as mean ± S.E.M. *p < .05, **p < .01, vs. the Con + Veh group; #p < .05, vs. the Sevo + Veh group.