Table 1. Mechanism of Cisplatin resistance .

Cisplatin resistance	Mechanism of action	Reference
Pre-target resistance	Avoiding to create cisplatin DNA adduct by decreasing cellular accumulation and efflux the cisplatin outside of the cell	7,10,11
On-target resistance	Enhanced DNA repair machinery and increase toleration of DNA
Post-target resistance	Alternation or signaling pathway after DNA deficiency through cisplatin exposure
Off-target resistance	An indirect cellular mechanism side effect that is not directly relative to cisplatin exposure but causes evasion of Apoptosis and Cisplatin cell death